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HThis represents the degree of dominance of the unfavored a allele in selection. The product of selection and dominance coefficients (i.e., s × h) represents the degree of selection against the Aa genotype group with respect to the AA genotype group.

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A value of h = 1 indicates that the Aa genotype group is equally unfavored as the aa genotype group. A value of h = 0 indicates that the Aa genotype group is equally favored as the AA genotype group. A value of h = 0.5 represents the additive model, where the selection against the Aa genotype group is half that of the aa genotype group.

Negative values of h (representing over‐dominance or “heterozygote advantage”) are not implemented. Instead use fitness coefficients to describe situations of over‐ or under‐dominance. Note, selection can be defined in terms of selection and dominance coefficients, or in terms of the three fitness coefficients, but not both. About UsThe Department of Human Genetics at the University of Pittsburgh's Graduate School of Public Health is dedicated to genetics research, teaching, and services. The department has three major research missions, which are (1) to develop and use genetic methods to investigate the causes and treatment of hereditary and acquired human illness, (2) to understand and explore the impact of genetics on public health, education, and disease prevention, and (3) to appreciate the role of genetic diversity within human populations.

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